PhD Student Infection Biology and Field Assisted Biofabrication (ID 2105)
AO Foundation
Short Description Fracture-related infection (FRI) remains one of the most challenging complications in orthopaedic trauma, frequently resulting in bone destruction, implant failure, and prolonged treatment. Recent evidence suggests that early infection-induced bone loss is primarily driven by neutrophil-mediated inflammation and proteolytic degradation, alongside classical osteoclast-driven pathways. This project (DONUT - Development of advanced Osteolysis Model drive by NeUTrophils) aims to further our knowledge on this topic by developing a novel human-relevant 3D in vitro model that integrates:
- Spatially organized bone constructs generated using Sound-Induced Morphogenesis
- Integration of immune cell populations including neutrophils
- Controlled introduction of Staphylococcus aureus
- Advanced molecular and imaging-based readouts
- Develop and optimise 3D biofabricated bone model with immune cells
- Establish infection models with Staphylococcus aureus
- Introduce and study neutrophil-driven inflammatory processes
- Apply advanced analytical techniques (e.g. Imaging, transcriptomics, cytokine profiling)
- Analyse and interpret experimental data
- Contribute to scientific publications and presentations
- Master's degree in biomedical engineering, biology, microbiology, or a related field
- Experience in cell culture and laboratory techniques (e.g. Molecular biology, microscopy, microbiology)
- Experience in neutrophil handling and culture
- Experience in planning and executing research experiments
- Strong interest in infection biology, immunology, and/or biomaterials
- Excellent communication skills in English
- Ability to work independently as well as collaboratively in an interdisciplinary environment
- High motivation and enthusiasm for research
- Experience with 3D cell culture or tissue models
- Knowledge of host-pathogen interactions or infection models
- Familiarity with biofabrication, hydrogels, or biomaterials
- Exposure to advanced imaging or omics approaches
- An interesting and varied job in an exciting and innovative organization
- The opportunity to be part of a highly committed international team
- Modern infrastructure
- High degree of flexibility regarding working hours and location (depending on operational requirements)
- Generous package of social benefits, including supplementary vacation days and pension scheme contributions
- Internal skills training opportunities and support for continued education
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