Senior Expert - Structural Bioinformatics (80-100%*)

About the role

Location: Basel, Switzerland
Full time, onsite, #LI-Onsite

Improving and extending people’s lives is what we do. It’s our purpose, our calling – the summit we’re always striving to reach.

But doing this consistently, at scale, for people around the world is no easy task. Getting patients the medicines they need presents a series of complex challenges that can only be overcome with curiosity, determination and the support of a strong, united team.

The Biologics Research Center (BRC) at Biomedical Research (BR) is looking for a structure bioinformatician / computational biologist to join the Bioinformatics and Biotherapeutics modelling team.
The team collaborates closely with experimental scientists and contribute to the advancement of biologics projects by assisting in the design, selection, optimization of biologics candidates.

The candidate will be an integral part of project teams with the responsibility of assisting scientists across the organization in the analysis and design of protein sequences and structures, advancing biologics projects starting from early discovery.

The candidate will apply, develop, and improve computational structural modelling methods to analyse data to improve or design functional properties of our drug candidates.

The candidate will collect, analyse, and integrate diverse type of data with structural data, also from different projects, to build predictive models, formulate hypothesis and generate knowledge.

This position requires a strong background in structure biology and bioinformatics

Your responsibilities include:

• Actively contributing to the biologics discovery pipeline, or innovation related programs, by applying structure-based modeling methods to design novel molecules, optimize current lead candidates, or design reagents at different stages of the drug discovery process
• Independently design, utilize and improve bioinformatics tools in the field of molecular modelling to analyse sequence and structure data for knowledge generation
• Work with experimental and computational scientists in BRC and in other departments to set standards, develop tools, algorithms and databases
• Independently identify, lead and be responsible for the development of innovative molecular modelling and bioinformatics solutions in the field of structure-based drug design by establishing internal or external collaborations
• Communicate data and analyses to broad scientific audience, technical and non-technical team members and colleagues

Role Requirements

What you will bring to the role:

• Ph.D. degree in Bioinformatics, Computational Biology, Data Science, Structural Biology or related field, or MS degree with 5+ years of relevant industry experience in a biomedical research environment using computational protein design methods, structure prediction tools, MD simulation tools such as MOE, Rosetta, PyMOL, Schrödinger or similar
• Demonstrated experience working in most of the following areas: structure-based drug design, homology modelling, ligand/receptor docking, MD simulations, fragment-based design, diversity/similarity structure-based analysis
• Proven knowledge in using major bioinformatics databases, tools and methods related to sequence and structure analysis of biologics molecules, including antibodies and antibody-like proteins, therapeutic proteins, viral vectors for cell and gene therapy indications, RNA
• Ability to implement and develop methods or adapt existing pipelines for the analysis of sequences and structures
• Knowledge of programming languages, i.e. Python and R, and Unix / high-performance computing environment, including software development practices as version control, testing, documentation, etc
• Collaborate in a matrix environment, working with scientists and teams in different areas to address projects’ specific needs
• Excellent interpersonal and communications skills; able to present own work and complicated concepts to multidisciplinary audiences

Why Novartis:
Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us!

Learn more here: and culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. rewards

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here:

*Restrictions on working flexibility may apply to this position and can be discussed at interview as required

Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail auf sjobs.brassring.com ansehen and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Commitment to Diversity & Inclusion:

We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.